Experimental charge density study on vitamin B12
نویسندگان
چکیده
منابع مشابه
Update on vitamin B12 deficiency.
Vitamin B(12) (cobalamin) deficiency is a common cause of megaloblastic anemia, a variety of neuropsychiatric symptoms, and elevated serum homocysteine levels, especially in older persons. There are a number of risk factors for vitamin B(12) deficiency, including prolonged use of metformin and proton pump inhibitors. No major medical organizations, including the U.S. Preventive Services Task Fo...
متن کاملStructural study on ligand specificity of human vitamin B12 transporters.
Studies comparing the binding of genuine cobalamin (vitamin B12) to that of its natural or synthetic analogues have long established increasing ligand specificity in the order haptocorrin, transcobalamin and intrinsic factor, the high-affinity binding proteins involved in cobalamin transport in mammals. In the present study, ligand specificity was investigated from a structural point of view, f...
متن کاملOral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency.
BACKGROUND Vitamin B12 deficiency is common, and the incidence increases with age. Most people with vitamin B12 deficiency are treated in primary care with intramuscular (IM) vitamin B12. Doctors may not be prescribing oral vitamin B12 formulations because they may be unaware of this option or have concerns regarding its effectiveness. OBJECTIVES To assess the effects of oral vitamin B12 vers...
متن کاملExperimental charge density from electron microscopic maps.
The charge density (CD) distribution of an atom is the difference per unit volume between the positive charge of its nucleus and the distribution of the negative charges carried by the electrons that are associated with it. The CDs of the atoms in macromolecules are responsible for their electrostatic potential (ESP) distributions, which can now be visualized using cryo-electron microscopy at h...
متن کاملExperimental charge density of N-phenylurea
Urea and its derivatives have been the subject of extensive experimental and theoretical studies, using many techniques, mainly because of interesting physical and chemical properties [1-4]. Here we report a preliminary results of charge density study of N-phenylurea using synchrotron diffraction data collected at beamline F1 at HASYLAB/DESY. Although known from literature [1], the structure wa...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section A Foundations of Crystallography
سال: 2005
ISSN: 0108-7673
DOI: 10.1107/s0108767305082346